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1

Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance

Plaza-Menacho, I, Morandi, A, Robertson, D, Pancholi, S, Drury, S, Dowsett, M, Martin, L-A, Isacke, C M

Journal:

Year:

2010

Language:

english

File:

PDF, 943 KB

english, 2010

2

Current concepts in RET-related genetics, signaling and therapeutics

Ivan Plaza-Menacho, Grzegorz M. Burzynski, Jan Willem de Groot, Bart J.L. Eggen, Robert M.W. Hofstra

Journal:

Trends in Genetics

Year:

2006

Language:

english

File:

PDF, 745 KB

english, 2006

3

RET in breast cancer: functional and therapeutic implications

Andrea Morandi, Ivan Plaza-Menacho, Clare M. Isacke

Journal:

Trends in Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 508 KB

english, 2011

4

73 Proffered Paper: Glial Cell Line-derived Neurotrophic Factor (GDNF) Signaling as a Target for Endocrine Therapy Resistance in Breast Cancer

A. Morandi, Q. Gao, P. Francica, A. Mackay, J.S. Reis-Filho, M. Zvelebil, M. Dowsett, L.A. Martin, I. Plaza-Menacho, C.M. Isacke

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 66 KB

english, 2012

5

Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase

Mologni, Luca, Redaelli, Sara, Morandi, Andrea, Plaza-Menacho, Ivan, Gambacorti-Passerini, Carlo

Journal:

Molecular and Cellular Endocrinology

Year:

2013

Language:

english

File:

PDF, 811 KB

english, 2013

6

Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy

Plaza-Menacho, I., Mologni, L., McDonald, N.Q.

Journal:

Cellular Signalling

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

7

Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans

Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.38 MB

english, 2014

8

Ras/ERK1/2-mediated STAT3 Ser727 Phosphorylation by Familial Medullary Thyroid Carcinoma-associated RET Mutants Induces Full Activation of STAT3 and Is Required for c-fos Promoter Activation, Cell Mitogenicity, and Transformation

Plaza-Menacho, I., van der Sluis, T., Hollema, H., Gimm, O., Buys, C. H. C. M., Magee, A. I., Isacke, C. M., Hofstra, R. M. W., Eggen, B. J. L.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

9

Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.

Plaza-Menacho, I., Mologni, L., Sala, E., Gambacorti-Passerini, C., Magee, A. I., Links, T. P., Hofstra, R. M. W., Barford, D., Isacke, C. M.

Journal:

Journal of Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 519 KB

english, 2009

10

Sorafenib Functions to Potently Suppress RET Tyrosine Kinase Activity by Direct Enzymatic Inhibition and Promoting RET Lysosomal Degradation Independent of Proteasomal Targeting

Plaza-Menacho, I., Mologni, L., Sala, E., Gambacorti-Passerini, C., Magee, A. I., Links, T. P., Hofstra, R. M. W., Barford, D., Isacke, C. M.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

11

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

Plaza-Menacho, I., Morandi, A., Mologni, L., Boender, P., Gambacorti-Passerini, C., Magee, A. I., Hofstra, R. M. W., Knowles, P., McDonald, N. Q., Isacke, C. M.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 2.98 MB

english, 2011

12

A Role for Glial Cell Derived Neurotrophic Factor Induced Expression by Inflammatory Cytokines and RET/GFR 1 Receptor Up-regulation in Breast Cancer

Esseghir, S., Todd, S. K., Hunt, T., Poulsom, R., Plaza-Menacho, I., Reis-Filho, J. S., Isacke, C. M.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 898 KB

english, 2007

13

GDNF-RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors

Morandi, A., Martin, L.-A., Gao, Q., Pancholi, S., Mackay, A., Robertson, D., Zvelebil, M., Dowsett, M., Plaza-Menacho, I., Isacke, C. M.

Journal:

Cancer Research

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

14

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

Dubey, B. N., Lori, C., Ozaki, S., Fucile, G., Plaza-Menacho, I., Jenal, U., Schirmer, T.

Journal:

Science Advances

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

15

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

Plaza-Menacho, Iván, Barnouin, Karin, Barry, Rachael, Borg, Annabel, Orme, Mariam, Chauhan, Rakhee, Mouilleron, Stephane, Martínez-Torres, Rubén J., Meier, Pascal, McDonald, Neil Q.

Journal:

Year:

2016

Language:

english

File:

PDF, 4.74 MB

english, 2016

16

RET receptor structure and function in MEN2

Plaza-Menacho, Ivan

Journal:

Endocrine Related Cancer

Year:

2017

Language:

english

File:

PDF, 711 KB

english, 2017

17

Novel targeted therapeutics for MEN2

Redaelli, Sara, Plaza-Menacho, Ivan, Mologni, Luca

Journal:

Endocrine Related Cancer

Year:

2018

Language:

english

File:

PDF, 670 KB

english, 2018

18

Hybrid histidine kinase activation by cyclic di-GMPâmediated domain liberation

Dubey, Badri N., Agustoni, Elia, BÃ¶hm, Raphael, Kaczmarczyk, Andreas, Mangia, Francesca, von Arx, Christoph, Jenal, Urs, Hiller, Sebastian, Plaza-Menacho, IvÃ¡n, Schirmer, Tilman

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 2.96 MB

2020

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